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Latest Posters

KingFisher - A Multifunctional Tool for Proteomics content piece image
Poster

KingFisher - A Multifunctional Tool for Proteomics

In the proteomics area with the increasing capacity of the mass spectrometers, sample preparation is becoming a limiting step for protein identification. Magnetic particle based technology provides a rapid and easy solution for automation of the sample preparation step.
KingFisher - A Multifunctional Tool for Proteomics content piece image
Poster

KingFisher - A Multifunctional Tool for Proteomics

In the proteomics area with the increasing capacity of the mass spectrometers, sample preparation is becoming a limiting step for protein identification. Magnetic particle based technology provides a rapid and easy solution for automation of the sample preparation step.
New 3D Black Substrate for Protein Microarrays with Improved Dynamic Range content piece image
Poster

New 3D Black Substrate for Protein Microarrays with Improved Dynamic Range

A competitive study analysing the background fluorescence and the detectable concentration range of a chosen antigen is presented. An Affymetrix Spotting roboter 417 arrayer was used for protein dotting. The analysis is based on fluorescence scanning experiments with an Affymetrix 428 array scanner at a gain of 60. Data analysis was made with ImaGene Premium 5.5.3 by Biodiscovery Inc.
High Throughput Technologies (HTT) content piece image
Poster

High Throughput Technologies (HTT)

This article aims to provide, with several real HTT system examples, a brief insight into how common, discrete tasks to HTT can be integrated into flexible, high throughput, automated systems as part of a corporate HTT strategy.
Optimizing the hERG Assay on the PatchXpress 7000A System for Compounds that Demonstrate Non-specific Binding content piece image
Poster

Optimizing the hERG Assay on the PatchXpress 7000A System for Compounds that Demonstrate Non-specific Binding

Eight compounds, astemizole, pimozide, dofetilide, cisapride, terfenadine, flunarizine, quinidine and imipramine were used to evaluate the effect of different assay conditions to overcome the effects of non-specific binding in our hERG assay on the PatchXpress 7000A system.
Reducing the Synthetic Burdens of Lead Structure Optimization: A Novel Software-Aided Approach content piece image
Poster

Reducing the Synthetic Burdens of Lead Structure Optimization: A Novel Software-Aided Approach

At the later stages of drug optimization it is beneficial to augment the select ADME properties of leads by making small structural changes that do not introduce any negative effects on the activity or toxicity profiles. By combining physicochemical property predictors and a critically evaluated database of biologically-acceptable substituents, the synthetic chemist can evaluate and reduce the number of derivative compounds that need to be synthesized to achieve optimal drug-like properties.
Development of an Analytical Data Management System (ADMS) to Accelerate the Selection of a Suitable API Form Through Salt and Polymorph Screening content piece image
Poster

Development of an Analytical Data Management System (ADMS) to Accelerate the Selection of a Suitable API Form Through Salt and Polymorph Screening

In this work, we discuss the acceleration of the preformulation process through the use of modern software systems. The data system discussed can read, process, store, retrieve, visualize and report a wide variety of data type—XRD, Raman, HPLC, NMR, TGA, DSC, chemical structures, properties and images—in a centralized and homogeneous way. A pilot study at a pharmaceutical company demonstrated possible time savings between 20% and 80% at various points in the preformulation workflow.
Advanced Dryness Detection for Improved Throughput and Yield during Evaporation content piece image
Poster

Advanced Dryness Detection for Improved Throughput and Yield during Evaporation

In many laboratories across a wide range of disciplines, removal of solvent from dissolved sample is a routine, daily procedure. This article demonstrates the great importance of paying sufficient attention to closely monitoring the drying process and presents solutions to save time and prevent sample loss.
Combining Lyophilization and Centrifugal Evaporation content piece image
Poster

Combining Lyophilization and Centrifugal Evaporation

Creating a fast drying process that results in soft, unattached & rapidly re-suspendable dry sample.
Metabonomics, Dietary Influences and Cultural Differences: A 1H NMR-Based Study of Urine Samples Obtained From Healthy British and Swedish Subjects content piece image
Poster

Metabonomics, Dietary Influences and Cultural Differences: A 1H NMR-Based Study of Urine Samples Obtained From Healthy British and Swedish Subjects

Here, we describe two investigations on healthy subjects designed to evaluate the variability in metabonomic data, in view of dietary influences and cultural trends.
siRNA Design Including Secondary Structure Target Site Prediction content piece image
Poster

siRNA Design Including Secondary Structure Target Site Prediction

Preliminary data underlines the correlation between the siRNA knockdown efficiency and the local free energy of the mRNA target site. There is a strong evidence that considering the mRNA secondary structure within the siRNA design algorithm will lead to more efficient siRNAs.
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