Latest App Notes & Case Studies

Need a routine analytical technique that can provide protein expression profiling and targeted drug imaging? MALDI Imaging is used to determine the spatial distribution of molecules in a tissue section, for more complete multiomic information.

Adeno-associated virus (AAV) technology has become a crucial method for delivering gene therapy drugs and vaccines. The quantitation of viral capsids enables researchers to ensure that AAV preparations are of high quality and potency. However, challenges remain with the accurate quantitation and detection of multiple AAV serotypes.

Lipid nanoparticles (LNPs) have emerged as effective delivery vehicles for mRNA vaccines and nucleic acid-based drugs. Hence, the analysis of their composition, stability, and biological interactions is essential in drug development and delivery.

Accelerated solvent extraction (ASE) is an effective extractable profiling technique. However, the poor solubility of certain compounds can result in result in reduced recovery rates and can compromise analytical accuracy.

Stringent safety requirements associated with the analyses of carcinogenic and mutagenic impurities can present significant challenges. Methods must achieve a high level of sensitivity and selectivity while maintaining sufficient sample throughput.

Many targets implicated in diseases are refractory to knockdown by traditional therapeutics like antibodies and small molecules. They represent an exciting new modality, repurposing small molecule chemical tools to achieve selective degradation

A major challenge preventing transformative gene therapies from reaching patients is the lack of fit-for purpose potency assays, which are some of the most important assays in an analytical package but are often the most complex and high-risk.

Custom oligo synthesis can result in the formation of impurities. Hence, final products must be characterized to ensure they meet quality assurance and control standards.

LC/MS methods can be used to analyze a wide range of oligo samples. However, ion-pairing reagents can interfere with analyses and present challenges in multi-use systems.

Formalin-fixed, paraffin-embedded (FFPE) tissue is a valuable resource in the retrospective proteomic analysis of clinical and non-clinical samples. However, sample preparation techniques typically involve laborious, time-consuming and potentially hazardous xylene-based deparaffinization steps.