Latest App Notes & Case Studies

CRISPR/Cas9 gene editing can result in off-target cleavage events, impacting the validity of your final results. Cleavage of unintended targets can cause impaired cell function, cell death or misleading conclusions. CIRCLE-seq is a sensitive in vitro assay that was developed to overcome the challenges associated with off-target screening.

Energy metabolism plays a central role in a wide variety of cellular and physiological processes. Therefore, a deep understanding of how disruption to energy metabolism impacts cells can help in therapeutic drug discovery and development.

Download this app note to discover a method of recombinant protein expression that enables correct protein folding and post translational modification, is suitable for high-density cell culture, and can produce both secreted and intracellular proteins of various species.

There is currently no effective cure or treatment to slow down or stop the progression of Huntington's disease (HD). One reason for this is the lack of accurate and easy-to-use HD models.

The cell therapy manufacturing process requires the guidance of chemical manufacturing and controls for analytical method development focusing on the critical quality attributes (CQAs).

Rare cells play pivotal roles in disease initiation, maintenance and progression. Yet, identifying these cells remains a difficult task for low-plex technologies, as it is not always clear a priori which biomarkers distinguish rare phenotypes from the remaining population.

In drug screening, conventional high-throughput applications evaluate only a few measurements and have limited breadth to detect diverse phenotypic changes caused by compound exposure.

Download this app note to discover a method that facilitates optimal and reproducible conditions and thus reliable results, provides optimal activity-based cytokine dosing plus saves reagent.

Many downstream experiments in molecular biology, such as next-generation sequencing, depend on the use of reasonably pure nucleic acid samples in adequate concentration ranges.

It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.