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Latest Posters

Assessing Microenvironment Immunogenicity Using Tumor Specimen Exomes: Co-detection of TcR-α/β V(D)J Recombinations Correlates with PD-1Expression content piece image
Poster

Assessing Microenvironment Immunogenicity Using Tumor Specimen Exomes: Co-detection of TcR-α/β V(D)J Recombinations Correlates with PD-1Expression

This is the first report of any unproductive recombinations in tumor specimen exome files, indicating opportunities to identify lymphocytes in the microenvironment that could have impacts on tumor development other than via antigen presentation to T-cells. Based on α/β relative recombination rates, α recombinations are more frequent. The association of detection of alpha-beta V(D)J recombinations, with high PD-1 RNA levels and high RNA levels representing antigen presenting functions.
Comparison of CD45+ Depletion Methods for Enrichment of Disseminated Tumor Cells in Bone Marrow Samples content piece image
Poster

Comparison of CD45+ Depletion Methods for Enrichment of Disseminated Tumor Cells in Bone Marrow Samples

Comparison of CD45+ depletion methods for enrichment of disseminated tumor cells in bone marrow samples.
Improved T Cell Activation Bioassays for Development of Bispecific Antibodies and Engineered T Cell Immunotherapies content piece image
Poster

Improved T Cell Activation Bioassays for Development of Bispecific Antibodies and Engineered T Cell Immunotherapies

Here we describe a platform of T cell activation bioassays for the development of CD3 bispecific antibodies and engineered T cell immunotherapies.
Exploiting Polypharmacology in Precision Oncology: Identification of Differential Kinase Off-targets Among Clinical PARP Inhibitors content piece image
Poster

Exploiting Polypharmacology in Precision Oncology: Identification of Differential Kinase Off-targets Among Clinical PARP Inhibitors

Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?
Validation of an Image-Based 3D Natural Killer Cell Mediated Cytotoxicity Assay content piece image
Poster

Validation of an Image-Based 3D Natural Killer Cell Mediated Cytotoxicity Assay

Here we describe a novel 3D NK cell mediated cytotoxicity (CMC) assay.
Immunotherapy on Chip: “Under the Microscope” Drug-induced Modulation of the Immune Response content piece image
Poster

Immunotherapy on Chip: “Under the Microscope” Drug-induced Modulation of the Immune Response

The immune system is a striking example of an integrated information system, engaged in coordinated host-protective activities. Organs-on-chip approach (OOC) models allow the direct simultaneous observation of hundreds of different cells, moving, interacting and responding to signals coming from the microenvironment nearby, that give access to a number of parameters describing the system that must be properly measured and elaborated.
Characterizing GPCR Activation Using Automated Live Cell Imaging content piece image
Poster

Characterizing GPCR Activation Using Automated Live Cell Imaging

Here we describe a live cell imaging based approach to detect GPCR activation using the Lionheart™ FX Automated Live Cell Imager and Gen5™ Microplate Reader and Imager Software.
MicroRNAs as Bile-Based Biomarkers in Pancreatic Cancer and Biliary Tract Cancers content piece image
Poster

MicroRNAs as Bile-Based Biomarkers in Pancreatic Cancer and Biliary Tract Cancers

In this study, the role of miRNAs has been assessed in a large cohort of pancreatic cancer.
Is Oxford Nanopore Technology Ready for Clinical Diagnostics? content piece image
Poster

Is Oxford Nanopore Technology Ready for Clinical Diagnostics?

Our objective is to validate diagnostic services using Oxford Nanopore’s Minion in the first instance and to evaluate the cost and performance compared to existing sequencing technology in areas such as tumour DNA sequencing (and circulating tumour DNA), virology, microbiology, genetics and HLA-typing.
Inhibiting CK2α from Outside the Active Site content piece image
Poster

Inhibiting CK2α from Outside the Active Site

Here we report the creation and characterization of a unique inhibitor of CK2a that targets a novel cryptic pocket and was developed using fragment-based methods.
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