Latest App Notes & Case Studies

Data-independent acquisition (DIA) has been shown to increase the quantitative reproducibility and accuracy of MS-based phosphoproteomics. This app note explores the impact of dia-PASEF on the speed and sensitivity of phosphoproteomics.

RNA-based therapies can modulate cells in a controlled and targeted manner, effectively acting as gene therapies. But, as with any therapeutic, RNA therapeutics must undergo strict quality control (QC) to ensure the product is exactly as specified, with no errors or alternate products.

The multi-attribute method (MAM) is a powerful LC-MS method that overcomes this challenge by simultaneously monitoring and quantifying multiple PQAs in a single injection.

Antibody drug conjugates (ADCs) are biotherapeutics, composed of small molecule drugs conjugated to an antibody scaffold, that have very complex molecular structures.

Traditional methods are often low throughput, time-consuming and lack linearity. However, advanced flow cytometry has emerged as a more efficient alternative for biologics development.

Quantitative real time PCR, often coupled with reverse transcription (RT-qPCR), is a powerful technique for detecting differences in the copy number of nucleic acids and can be used for analysis of gene expression.

Lipid nanoparticles (LNPs), comprised of ionizable lipids, are used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system, as in the initial mRNA-based COVID vaccines.

Products based on mRNA have broad potential for use as therapeutics, and because mRNA leverages the translational machinery of the host cells, there is a significantly reduced risk of unwanted post-translational modifications.

Download this app note to discover a SWATH DIA workflow that:
Has the speed and sensitivity to acquire high-quality, high-resolution MS/MS data
Reduces the need to generate experimental libraries
Was used to identify 2-fold more proteins than a DDA workflow

One method of analysis commonly used to ensure drinking water quality is the measurement of volatile organic compounds (VOCs). These compounds can appear in drinking water by contamination from numerous sources, including industrial and commercial operations.