Latest App Notes & Case Studies

Outsourcing quality management activities can save biomanufacturers time, money and resources. It can support scientists in bringing life-changing therapeutics to market swiftly and efficiently.

Both RUO and cGMP compliance play important roles in the drug discovery pipeline. However, meeting regulatory demands can be a challenge when accelerating new drugs to the clinic.

Discover an automated solution for the consolidation and ranking of your metabolite structures. Explore a workflow that utilizes both EAD and CID data for the most confident characterization and streamlined data acquisition.

Discover an automated processing workflow that utilizes both EAD and CID data for the most confident characterization of pharmaceutical drug metabolites.

Metabolism is a key driver of CAR-T cell fitness and function. Hence, metabolic preconditioning methods can enhance the bioenergetic capacity of CAR-T cells in culture, supporting their persistence and antitumor activity

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only provides an average of the transcripts expressed across your sample of cells.

Protein-targeting chimeras (PROTACs) have gained significant attention recently due to their high potency in nanomolar drug concentrations and target selectivity. However, low test concentrations in complex matrices present analytical challenges.

Understanding the effects of in vitro drug metabolism is a key aspect of drug discovery and development. However, researchers must be able to make confident decisions quickly and easily.

Glucuronidation is an essential metabolic pathway for drug clearance and its characterization is crucial for optimizing the efficiency and safety of drug candidates.

Early ADME studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation. Glucuronide conjugation is difficult to characterize using MS/MS alone, therefore fragmentation is also required to obtain structural information.