Drug Targets – Multimedia

Designing and performing assays that accurately measure small molecule binding kinetics is an important part of the drug discovery process. It allows researchers to predict the efficacy of potential novel therapeutics and make quick decisions about weak binders.

Target-based drug discovery (TBDD) has been the top drug discovery approach for ~30 years. TBDD approaches were developed to improve drug discovery by reducing the costs of bringing a drug to market, increasing throughput and being more straightforward and efficient than other methods.

Conventional bioassays often require labeled detection reagents to provide a measurable readout. However, modifications to molecular structure and/or function can skew results, and non-specific binding of the labels themselves can lead to an unwanted background signal.

Dysfunctional metabolism is associated with a growing number of different disease states. The ability to examine the genes, proteins and pathways that modulate energy metabolism is therefore a promising new avenue for drug discovery.

Download this infographic to learn how to optimize protein-based drug discovery using modern silicon-based DNA synthesis.

The journey to discovering novel drug targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures to bridge the gap between 2D cell cultures and in vivo animal models.

Speaking at The Landscape of Cancer Research 2021, Prof. Emanuel Petricoin from The George Mason University, presented his talk on pharmacoproteomics.

Download this infographic to explore key milestones and assay types, innovations driving high-throughput screening (HTS) and a typical HTS workflow.

Download this eBook to learn more about water in drug production and QC and its role in QC failure.

Download this eBook to learn more about how to link genomics with proteomics to accelerate the search for drug targets, understand COVID-Associated Multisystem Inflammatory Syndrome in children and much more.