Drug Targets – News and Features

Cells contain molecular machinery that targets and disposes of unwanted proteins. Scientists would like to hijack this process to control proteins involved in cancer and other diseases, using a type of molecule called a molecular glue degrader.

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes.

Precision treatment for rheumatoid arthritis is key. New research has used a cellular atlas to outline the variety of cellular causes, which may inform targeted, effective therapies.

Using a technique that has shown promise in targeting cancer tumors, a Duke Health team has found a way to deploy a molecular warhead that can annihilate the bacterium that causes Lyme disease.

This article focuses on the use of high-throughput screening approaches in drug discovery and discusses the latest developments in this area.

A new study has revealed some of the mechanics underlying how breast cancer cells invade healthy tissues. The research, which may offer new drug targets against the spread of cancer cells (metastasis), is published in Advanced Science.

An enzyme that may help some breast cancers spread can be stopped with an antibody created in Cold Spring Harbor Laboratory. With further development, the antibody might offer an effective drug treatment for those same breast cancers.

A recent discovery, published in PLoS Genetics, challenges the “rulebook” of DNA. We speak with the first author, Dr. Jamie McGowan, to learn about the accidental finding and what it means for synthetic biology.

A blood test that identifies biomarkers linked to bipolar disorder could improve diagnosis of the condition, ensuring patients get the right treatment.

A new study has identified how the gene APOE4 contributes to Alzheimer's disease, providing a potential drug target.