Advanced Cell Models – News and Features

This article focuses on the use of high-throughput screening approaches in drug discovery and discusses the latest developments in this area.

Human intestinal organoids have shed new light on the potential causes of Cronkhite-Canada syndrome, a rare condition characterized by abundant non-cancerous growths or polyps in the intestine.

Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.

Researchers used gut organoids to perform a systematic CRISPR screening of 1800 human transcription factors and identified ZNF800 as a key regulator of the differentiation of a specific gut cell type, the enteroendocrine cells.

In a new study, Yale researchers revealed the molecular origins of the developmental differences that distinguish primates from mice.

Lung cancer cells that metastasize to the brain survive by convincing brain cells called astrocytes that they are baby neurons in need of protection, according to a study by researchers at Stanford Medicine.

A human lung-on-a-chip has been used to model radiation damage, revealing key insights into early disease development and new opportunities for drug development.

Skin organoids offer a powerful platform for drug discovery in the ongoing fight against the virus formerly known as monkeypox.

Shantanu Dhamija discusses how AI can help scientists to fully embrace organoids in drug discovery.

An expert at Cincinnati Children’s working with a team of colleagues in Japan has applied organoid technology to make a significant discovery in the race to develop effective COVID treatments.